Who We Are?
We are an Innovative Biotech Startup that conducts preclinical research for intractable conditions
Our MissioN
To develop a treatment for Myelodysplastic Neoplasms (MDS), based on the capability of specific RNA therapeutics to reprogram DNA methylation, which has been identified from a platform with the real potential to deliver novel drugs for oncology indications and rare diseases.
Board of Directors

Giovanni Amabile, PhD
Executive Chairman

Giovanni Amabile, PhD
Executive Chairman
Previously, he served as the CEO of Enthera, where he secured the largest VC-backed Series A funding for an Italian biotech. Before that, he was the CSO at ADIENNE, where he achieved MA approvals in the US for thiotepa in 2017. He has strong regulatory expertise in both the US and EU, and a successful track record in obtaining IND approvals.
- Email:gamabile@aptadir.com

Simone Braggio
Board Member

Simone Braggio
Board Member
He has over 30 years of experience in both Big Pharma (GSK and affiliates) and CROs (Aptuit and Evotec), holding increasingly responsible roles in research, strategic partnership development, and innovative business model implementation. At GSK, he played a key role in redefining lead optimization strategies to reduce clinical phase attrition. At Aptuit, he was instrumental in redefining and implementing an innovative business model capable of attracting integrated projects and long-term partnerships (Partnership Research Organization; PRO). He is also the author or co-author of over 25 scientific articles and is a regular speaker at international conferences and meetings.

Davide Santi
Board Member

Davide Santi
Board Member
He began his career in the investment sector at Amadeus Capital Partners in Cambridge as an analyst, later becoming an investment manager at an Italian investment fund focused on healthcare, where he managed direct investments. He also worked in health economics & market access at the pharmaceutical company Amgen and subsequently as a manager at UCB. He holds a degree in Biotechnology from the University of Padua, completed the international master’s in health economics (MIHMEP) at SDA Bocconi with a scholarship, and in 2020, finished the financial analyst training course at AIAF, obtaining the CIIA certification.
Scientific Founders

Annalisa Di Ruscio, MD, PhD
Founder

Annalisa Di Ruscio, MD, PhD
Founder
She has over 15 years of expertise in RNA biology and DNA methylation, with a focus on blood cancers, particularly Myelodysplastic Syndromes (MDS). She is the author of several high-impact publications, including works in Nature and Nature Communications. Additionally, she is a co-founder of SpeaRNA.

Vittorio De Franciscis, PhD
Founder

Vittorio De Franciscis, PhD
Founder
He has over 35 years of expertise in aptamer technology.

Daniel G. Tenen, MD
Founder

Daniel G. Tenen, MD
Founder
He has over 30 years of expertise in gene regulation of normal and cancer cells and is a world-renowned leader in leukemia research. Additionally, he is a co-founder of Believer Inc. and SpeaRNA.

Marcin Kortylewski, PhD
Founder

Marcin Kortylewski, PhD
Founder
He is an expert in oligonucleotide therapeutics with over 20 years of experience. Additionally, he is a co-founder of Duet BioTherapeutics.
